Characterization of a New Small Bowel Adenocarcinoma Cell Line and Screening of Anti-Cancer Drug against Small Bowel Adenocarcinoma
نویسندگان
چکیده
منابع مشابه
Adenocarcinoma of Small Bowel
Small bowel cancer is one of the rarest cancers in the gastrointestinal tract. The diagnosis is usually late and most patients presented with the advanced stage. Because of this rarity, there is limited data when making decisions for treatment and biological behavior. Most forms of the cancer occur in the duodenum with surgery being the treatment of choice if the cancer is operable. Chemotherap...
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Comprising about 2 % of all gastrointestinal malignancies, malignant tumors of the small bowel are relatively rare 1, adenocarcinomas being the most frequent among them. Their peak incidence, slightly higher in males than in females, is in the 7 th decade.2 More often they are found in the jejunum or duodenum. In the jejunum, adenocarcinomas are usually located within the first 30 cm distally o...
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Small bowel adenocarcinoma (SBA) is an aggressive disease with limited treatment options. Despite previous studies, its molecular genetic background has remained somewhat elusive. To comprehensively characterize the mutational landscape of this tumor type, and to identify possible targets of treatment, we conducted the first large exome sequencing study on a population-based set of SBA samples ...
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RATIONALE Small bowel adenocarcinoma (SBA) is an uncommon gastrointestinal cancer, thus limited data about treatment for advanced disease are available. The lack of specific guidelines has justified the use of therapeutic protocols usually applied in advanced colorectal cancer. Few and preliminary data have suggested possible clinical benefit from the use of target therapy such as bevacizumab a...
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Introduction. Small bowel adenocarcinoma is a rare tumor, with a still not well studied tumorigenesis process, and non-specific symptoms that cause a delay in the diagnosis and consequently a worst outcome for the patient. Videocapsule endoscopy (VCE) and double-balloon enteroscopy (DBE) have revolutionized the diagnosis and management of patients with small bowel diseases. Surgery is the treat...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2015
ISSN: 0002-9440
DOI: 10.1016/j.ajpath.2014.10.006